Research Interest:
1) Protein oxidation induced by light, chemicals and radicals
2) Stable modifications and markers of oxidative stress
3) Kinetics of biochemical processes
4) Fast photochemical reactions induced by aromatic sensitizers – from transient species to stable products
Grant:
- Two faces of iodide in oxidative stress. Investigation of iodide influence on oxidative stress, Sonata 12, active (2017-2019)
- Do sunscreens damage skin proteins? Preludium, NCN, 2011/03/N/ST4/01290 – accomplished (2012-14)
PUBLICATIONS:
- Casaril, A.M., Ignasiak, M.T., Chuang, C.Y., Vieira, B., Padilha, N.B., Carroll, L., Leonardao, E.J., Savegnago, L., Davies, M.J., Selenium-containing indolyl compounds: Kinetics of reaction with inflammation-associated oxidants and protective effect against oxidation of extracellular matrix proteins, Free Radical Biology and Medicine, 113, 395-405 (2017)
- Karimi, M., Ignasiak, M.T., Chan, B., Croft, A.K., Radom, L., Schiesser, C.H., Pattison, D.I., Davies, M.J., Reactivity of disulfide bonds is markedly affected by structure and environment: Implications for protein modification and stability, Scientific Reports, 6, 38572 (2016)
- Storkey, C., Pattison, D.I., Ignasiak, M.T., Schiesser, C.H., Davies, M.J., Kinetic of reaction of peroxynitrite with selenium- and sulfur-containing compounds: Absolute rate constants and assessment of biological significance, Free Radical Biology and Medicine, 89, 1049-1056 (2015)
- Scuderi, D., Ignasiak, M.T., Serfaty, X., De Oliveira, P., Houee-Levin, C., Tandem mass spectrometry and infrared spectroscopy as tool to identify peptide oxidized residues, Physical Chemistry Chemical Physics, 17 (39) 25998-26007, 2015
- Ignasiak, M.T., Houee-Levin, C., Kciuk, G., Marciniak, B., Pedzinski, T., A reevaluation of the photolytic properties of 2-hydroxybenzophenone-based UV sunscreens: Are chemical sunscreens inoffensive? ChemPhysChem, 16 (3) 628-633, 2015
- Pedzinski, T., Bobrowski, K., Ignasiak, M., Kciuk, G., Hug, G.L., Lewandowska-Andraloic, A., Marciniak, B., 3-Carboxybenzophenone (3-CB) as an efficient sensitizer in the photooxidation of methionyl-leucine in aqueous solutions: Spectral, kinetic and acid-base properties of 3-CB derived transients, Journal of Photochemistry and Photobiology A: Chemistry, 287, 1-7, 2014
- Ignasiak, M., Pedzinski, T., Rusconi, F., Filipiak, P., Bobrowski, K., Houee-Levin, C., Marciniak, B., Photosensitized oxidation of methionine-containing dipeptides. From the transients to the final products, Journal of Physical Chemistry B, 118 (29), 8549-8558, 2014
- Ignasiak, M., Marciniak, B., Houee-Levin, C., A long story of sensitized one-electron photo-oxidation of methionine (Review), Israel Journal of Chemistry, 54 (3) 248-253, 2014
- Ignasiak, M., De Oliveira, P., Houee-Levin, C., Scuderi, D., Oxidation of methionine-containing peptides by ·OH radicals: Is sulfoxide the only product? Study by mass spectrometry and IRMPD spectroscopy, Chemical Physics Letters, 590, 35-40, 2013
- Ignasiak, M., Scuderi, D., De Oliveira, P., Pedzinski, T., Rayah, Y., Houee-Levin, C., Characterization by mass spectrometry and IRMPD spectroscopy of the sulfoxide group in oxidized methionine and related compounds, Chemical Physics Letters, 502 (1-3), 29-36, 2011